INK 128 (MLN0128)
INK 128 (MLN0128)
CAS: 1224844-38-5
Molecular Formula: C15H15N7O
INK 128 (MLN0128) - Names and Identifiers
INK 128 (MLN0128) - Physico-chemical Properties
| Molecular Formula | C15H15N7O |
| Molar Mass | 309.33 |
| Density | 1.64 |
| Melting Point | 270-272°C (dec.) |
| Boling Point | 598.8±60.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 25 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| pKa | 3.77±0.30(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | The INK 128 exhibited inhibitory activity against mTOR enzymes and was more than 100-fold selective for PI3K kinase. As a TORC1/2 inhibitor, INK 128 inhibits the phosphorylation of the downstream substrates of TORC1, S6 and 4EBP1. In addition, the INK 128 also showed potent inhibitory effects on cell lines resistant to rapamycin and pan-PI3K inhibitors. |
| In vivo study | In a ZR-75-1 breast cancer xenograft model, treatment with INK 128(0.3 mg/kg/day) demonstrated tumor growth inhibition. Daily oral administration of INK 128 inhibits angiogenesis and tumor growth in a variety of transplant models. |
INK 128 (MLN0128) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.233 ml | 16.164 ml | 32.328 ml |
| 5 mM | 0.647 ml | 3.233 ml | 6.466 ml |
| 10 mM | 0.323 ml | 1.616 ml | 3.233 ml |
| 5 mM | 0.065 ml | 0.323 ml | 0.647 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: INK 128 (MLN0128) Visit Supplier Webpage Request for quotationCAS: 1224844-38-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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